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Product Spotlight

Introducing the Nutrigesic Kit™
The Nutrigesic Kit is designed for short-term nutritional support after injury, trauma, or surgery.* To order the Nutrigesic Kit  click here. Practitioners, please log in and click here to read more about the Nutrigesic Kit and our special offer. Access additional information here: practitioner information sheet, clinical research report, or patient trifold.
NEW! GingerPro™
GingerPro is small, safe, and powerful.* Purity, potency, and stability of the ginger extract are guaranteed with super-critical CO2 extraction. GingerPro can provide benefit for pregnancy-induced nausea, menstrual discomfort, muscle soreness from exercise, and nausea from medications.* Read More

Latest News

September is National Pain Awareness Month

We have teamed up with experts at Mayo Clinic to provide you with several educational articles on pain. Click here to learn more about what happens in the body when you feel pain, as well as some self-care, rehabilitation, and lifestyle strategies to help you manage pain. 

Bromelain

Bromelain is a dietary supplement that may have some benefits for pain management.

https://www.thorne.com/education/health-lifestyle/ART-20208627/bromelain

Curcumin

Curcumin is a dietary supplement that may have some benefits for pain management.

https://www.thorne.com/education/health-lifestyle/ART-20208628/curcumin

Magnesium

Magnesium is a dietary supplement that may have some benefits for pain management.

https://www.thorne.com/education/health-lifestyle/ART-20208629/magnesium

Melatonin

Melatonin is a dietary supplement that may have some benefits for pain management.

https://www.thorne.com/education/health-lifestyle/ART-20208630/melatonin

Understanding pain

Pain is an unpleasant but unavoidable fact of life. Here's an overview of the science behind why you hurt.

https://www.thorne.com/education/health-lifestyle/ART-20208632/understanding-pain

Treating pain: Overview

You have many options for pain relief. This overview includes descriptions of health care providers who treat pain.

https://www.thorne.com/education/health-lifestyle/ART-20208633/treating-pain-overview

Self-care approaches to treating pain

For many types of pain, self-care steps can provide relief.

https://www.thorne.com/education/health-lifestyle/ART-20208634/self-care-approaches-to-treating-pain

Treating pain: Conventional medical care

Medications play an important role in pain relief, but it's important to be aware of their side effects.

https://www.thorne.com/education/health-lifestyle/ART-20208635/treating-pain-conventional-medical-care

Pain rehabilitation

Pain rehabilitation, including physical and occupational therapy, can help reduce your pain and improve quality of life.

https://www.thorne.com/education/health-lifestyle/ART-20208636/pain-rehabilitation

Integrative approaches to treating pain

Here's what you need to know about integrative approaches to treating pain.

https://www.thorne.com/education/health-lifestyle/ART-20208637/integrative-approaches-to-treating-pain

Nutrition and pain

The right food choices can help with pain management. Here's how.

https://www.thorne.com/education/health-lifestyle/ART-20208638/nutrition-and-pain

Lifestyle strategies for pain management

Your daily choices, including how much sleep and physical activity you get, play a key role in managing ongoing pain.

https://www.thorne.com/education/health-lifestyle/ART-20208639/lifestyle-strategies-for-pain-management

Thorne Sponsors Kilimanjaro Summit Expedition

We are proud to announce that Thorne has sponsored a research expedition to summit Mt. Kilimanjaro in Tanzania, Africa beginning August 7th, 2016.  The expedition research team will test the effect of 1,000 mg daily of nicotinamide riboside on altitude tolerance, cardiovascular fitness, and team cohesion at the highest point on the African continent (19, 341 ft).  The study will add to the body of sophisticated studies conducted at altitude. Metrics include gut microbiome community structure/diversity (genetic), gut microbiome metabolome (untargeted), pulmonary function, exhaled NO, echocardiogram, oxygen saturation, sleep, and a series of other physiologic metrics involved in thriving at extreme altitudes.  It will also be among the rare studies that applies these types of molecular and physiologic metrics to the study of team cohesion in extreme environments.

 

Members of two key Mayo Clinic teams will be central to the expedition. This includes the team at the Human Integrative and Environmental Physiology Laboratory, as well as the Aerospace Medicine and Vestibular Research Laboratory. The expedition leader is Conrad Anker, who has climbed Mount Everest three times and is one of the most respected alpinists of our era.  Anker is noted for recently having led the only team to summit the Shark’s Fin on Mount Meru in the Himalayas, an iconic spire that repelled some of the world’s best alpinists for three decades.  Other sponsors include The North Face, Philips, and Biovotion.  Each sponsoring partner brings unique technology and know-how to the high altitude environment. Follow the climb on Twitter starting August 7th #kiliclimb2016.

US Rowing Names Thorne Research as its Newest Partner

PRINCETON, N.J. – USRowing is proud to announce that Thorne Research has signed as the exclusive dietary supplement partner of USRowing, providing national team members with effective and safe supplements to support athlete health. As part of the multi-year agreement, Thorne will provide products to U.S. National Team athletes and will offer benefits to the rowing community through a health portal and educational campaign.

Major advances in the research, development and monitoring of dietary supplements has enabled Thorne Research to provide elite athletes with supplements that can aid in overall health as well as accelerate recovery from the day-to-day rigors of training after the athletes’ food and nutrition practices have been maximized. Thorne Research will provide USRowing athletes with products that have the highest level of certification, baseline nutritional level testing through WellnessFX, educational materials and risk protection.

“Our athletes’ health is our highest priority and cannot be placed at risk. Athletes may have nutritional or physiological demands that require supplementation, and USRowing’s partnership with Thorne Research will ensure that our athletes are receiving safe, clean and carefully monitored and tested dietary supplements,” saidDr. Jo Hannafin, USRowing’s team physician. “It is critically important that standards for quality, safety and content be demonstrated for dietary supplements that may be used by our athletes.”

In addition, athletes will have access to reliable health information from Mayo Clinic, which has been compiled for easy access on the Thorne Research website. This content helps athletes evaluate supplement usage and understand supplement labels, manufacturing and regulations, all provided by an objective resource.

“USRowing is synonymous with quality and success. We at Thorne Research are excited to be part of this winning tradition and also take tremendous pride in the quality of our product,” said Paul Jacobson, Thorne Research CEO. “Through this partnership, we look to become an integral part of the health and wellness regimen of these great athletes and the rowing community.”

“The health and well being of the rowing community is important to USRowing, and we are proud to work with a company whose products are scientifically formulated, rigorously studied, clinically researched and NSF-certified for sport. The health portal and product site (https://usrowing.thorne.com) includes the same products offered to our elite athletes for those members who choose to use supplements in addition to food and nutrition practices,” said Beth Kohl, USRowing’s chief marketing officer. “USRowing is collaborating with Thorne Research and the Mayo Clinic on a health and wellness platform featuring broad-based content focused on athlete health. Partnering with Thorne Research will bring a heightened focus on health and nutrition to the rowing conversation, providing benefits for athletes at every level. We are thrilled they have joined our team.”  

USRowing and Thorne Research recommend that anyone considering using a supplement first check with their primary care specialist or registered dietitian.

About USRowing
USRowing is a nonprofit organization recognized by the United States Olympic Committee as the governing body for the sport of rowing in the United States. USRowing has 85,000 individual members and 1,300 member organizations, offering rowing programs for all. USRowing receives generous support from the National Rowing Foundation and its corporate sponsors and partners.

Original article by Sarah Marshall - July 13, 2016

Eight NGBs Sign Nutritional Supplement Brand

A nutritional supplement manufacturer blessed by the U.S. Olympic Committee has signed sponsor deals with national governing bodies in eight sports, breaking through in a category long suppressed by connections to failed PED tests.

Sandpoint, Idaho-based Thorne Research has deals in place to sponsor U.S. national teams in gymnastics, rugby, triathlon, rowing, pentathlon, fencing, taekwondo and softball, with plans to complete more in both summer and winter sports in the coming weeks, said Tom Shepard, chief marketing officer and partner at 21 Sports & Entertainment Marketing Group, which represents Thorne.

The agreements vary slightly by sport, but all will deliver to athletes and teams Thorne products that have been cleared by the NSF Certified for Sport program, which offers independent testing of products and the facilities in which they are manufactured.

Thorne also will provide NGBs and their athletes with a Wellness FX program that offers customized dietary and workout protocols, which can be tweaked and tracked through blood tests, as well as nutrition-based education programs tailored to athletes in each sport.

Each deal is for two years, with an option for a two-year extension, taking them beyond the coming Rio Olympics. Thorne would not disclose financial terms.

Spurred by athletes’ desire to use supplements, coupled with the fear that those supplements might cause them to test positive for banned substances, the USOC three years ago began a vetting process in search of a product line that it could recommend to competitors. It landed on Thorne, then worked with the company on a program that it could offer to the NGBs.

“The biggest problem with supplements in general is that the stuff geared for high performance tends to be spiked with some sort of drug to generate that performance,” said Paul Jacobson, Thorne Research CEO. “What the athletes are most concerned about is banned substances. At Thorne, we have never allowed anything on the banned substance list in our plant. Ever.”

Thorne’s primary distribution channel thus far has been through physicians who recommend the product to their patients. Working with the NGBs offers a chance to broaden that reach, increasing the brand’s exposure among athletes and their family and friends.

“They’ve chosen this strategy because, from an aspirational standpoint, this is it,” said Shepard, a former Visa marketing executive who structured the deals. “If it’s good enough for an aspiring Olympian, it’s good enough for Joe or Jill weekend athlete. It’s the concentric circle. When you look at a population base like [an NGB’s members] and how they influence those around them, that becomes a big number.”

USOC dieticians worked with Thorne to determine which of the company’s more than 400 products would be submitted for NSF certification and then made available to athletes. Six will be available initially — including an amino acid complex, a fish oil product and a vitamin D supplement — with the product line expanding to 19 by the end of July and 25 by January.

One of the Thorne products will have particular relevance for athletes headed to Rio: a probiotic designed to combat infection, which some say will be a risk for athletes competing in events in polluted waters, such as sailing, rowing, open-water swimming and triathlon.

Triathletes are an especially attractive target market for Thorne, because most already use supplements or would like to do so, said USA Triathlon CEO Rob Urbach. USA Triathlon’s membership of about 500,000 includes not only those building toward Rio, but the many “weekend” athletes who enter one or two events a year but train year-round.

“The supplement category has been a difficult category because of the perceptions of tainted products and potentially false advertising claims,” Urbach said. “The USOC was on a quest to find a supplement partner that they could trust, not so much for a sponsorship or licensing deal, but as a supply source to the athletes who didn’t want to risk ruining their career by using a tainted product.”

By Bill King, Senior Writer for Sports Business Journal

June 6, 2016

Thorne Research Partners with Multiple U.S. NGBs for Sport

New York, June 7, 2016 — In a move to bring the highest level of nutritional science and quality to the well-being of their athletes, elite and professional teams are vetting the most effective and safest nutritional supplements to support athlete health. Seven U.S. National Governing Bodies (NGB’s) have signed partnership agreements with Thorne Research to be their exclusive nutritional supplement partner, and agreements with several additional NGB’s are pending. These multi-year agreements will launch in 2016.

Thorne Research’s participation, in collaboration with the NGB’s coaches, doctors, and sports science specialists, will be integral to the health and wellness programs within these prestigious governing bodies, including USRowing. “Our athletes’ health is our highest priority and cannot be placed at risk. Athletes may have nutritional or physiological demands that require supplementation, and USRowing’s partnership with Thorne Research will assure that our athletes are receiving safe, clean, and carefully monitored and tested nutritional supplements," says Dr. Jo Hannafin, USRowing’s Head Team Physician. “It is critically important to ensure that standards for quality, safety, and content be demonstrated for nutritional supplements that may be used by our athletes,” she says.

As part of the NGB partnerships, Thorne Research will provide the NGB’s National Team members nutritional supplement products with the highest level of certification, baseline nutritional level testing through WellnessFX, educational materials, and risk protection with product liability insurance.  In addition, these elite athletes will have access to reliable health information from Mayo Clinic, which has been compiled for easy access on the Thorne Research website. This content will help athletes evaluate nutritional supplement usage and better understand nutritional supplement labels, manufacturing, and regulation, all provided by an objective resource. Thorne Research is also embarking on several clinical research studies at Mayo Clinic, including the effect of nicotinamide riboside on brain health in collegiate football players, the effect of nicotinamide riboside on altitude acclimatization and team cohesion during an ascent of Mt. Kilimanjaro, and a study of the microbiome in elite athletes.

Steve Penny, CEO of USA Gymnastics, is keenly aware of the unique demands placed on athletes.  Mr. Penny stated, “Athlete performance is a function of many variables, and proper nutrition is a key fundamental element.  The human body is designed to perform at its optimal level when the right balance of nutrients is provided to keep the athlete healthy and strong.  Often times, the competition environment can make it difficult for an athlete to have access to food products that meet their individual nutritional needs, especially when traveling abroad.”

Major advances in the development, medical research, and monitoring of nutritional supplements has enabled Thorne Research to provide elite athletes with nutritional supplements that can assist in accelerating recovery from exercise-induced muscle damage that can result from the day-to-day rigors of training and competition.

“Our partnership addresses a great need on the part of competitive and elite athletes. No longer must these athletes fend for themselves trying to figure out which nutritional supplements to take, and where to obtain a safe, clean, and reliable source of nutritional supplements.  This partnership follows years of hard work by the NGB’s to help the athletes address that problem. We are honored that these prestigious National Governing Bodies are working with us because of our approach to providing nutritional supplements that are scientifically formulated, rigorously studied, clinically researched, and NSF Certified for Sport®,” states Paul Jacobson, CEO of Thorne Research.

As athletes reach the highest levels of competition and become more efficient in their sport, they stress specific groups of muscles day in and day out. This daily process of stress and repair requires that their bodies receive very specific ranges of vitamins, minerals, and botanicals in order to perform optimally. For example, competing in a high-stress environment – that is also away from home – requires nutritional supplement products such as a probiotic supplement that provides optimal balance of good bacteria in the gut, and an iron supplement that promotes the formation of new red blood cells, thus optimizing the body’s ability to carry oxygen throughout the athlete’s body.

Official Partners Include:

USA Gymnastics

USA Triathlon

USA Rugby

USA Taekwondo

USRowing

Research Highlights on Dietary Supplements

A lot of research is overlooked when it comes to nutritional supplement products, which is understandable because there are more than two million peer-reviewed journal articles published every year. Fortunately, we have reviewed some of the newest and best research results so we can keep you up-to-date on what’s being revealed about the benefits of using nutritional supplement products. 


A recent study found that by supplementing aging mice with nicotinamide riboside, tissue maintenance and regeneration were enhanced and lifespan was increased. Click here for more information.


In a long-term prospective study of male physicians who were initially healthy at the time the study began (18,530 physicians, age 40 or older, from the Physicians’ Health Study), multi-vitamin/mineral use for at least a 20-year period was associated with a lower risk of major cardiovascular disease-related events. Click here for more information.

Thorne Research Announces Clinical Study to Assess Nicotinamide Riboside on Brain NAD+ in College Football Players

Mayo Clinic, University of Minnesota and ChromaDex to Collaborate on Study

NEW YORK, April 13, 2016 – Thorne Research and ChromaDex Corp. (OTCQX: CDXC) announced today a research endeavor with Mayo Clinic and the University of Minnesota Clinical and Translational Science Institute, regarding a planned clinical study to assess the effect of Nicotinamide Riboside (NR) on brain NAD+ in college football players.

The randomized, placebo controlled, double-blind study will enroll healthy male collegiate football linemen, not having a history of more than 3 concussions. Participants will take either 750 mg per day of Nicotinamide Riboside (NR) or placebo for 84 days. Pre- and post-intervention evaluations include physical assessment, blood tests for safety and toxicity monitoring, blood tests for biomarkers, neurologic testing, quality of life questionnaires, and real time measurement of brain NAD, using 31P MRS.

The primary outcome of the study is to measure the change in brain NAD+ levels over 3 months. The study is expected to begin in May 2016 with final data collected by March 2017.

The study will utilize advanced 7 Tesla in vivo 31P Magnetic Resonance Spectroscopy (MRS) for noninvasive measurement of brain NAD+ concentrations, NAD+/NADH ratio, and ATP, using a method pioneered by Xiao-Hong Zhu, Ph.D., Associate Professor the University of Minnesota Center for Magnetic Resonance Research.

The principal investigators of the study are Dr. Zhu and Brent A Bauer, MD, Director of the Well Living Lab and Director of the Complementary and Integrative Medicine Program at Mayo Clinic in Rochester, Minnesota.

Paul Jacobson, CEO of Thorne Research, stated, “We now have data showing that nicotinamide riboside raises NAD+ in the blood and in the brains of animals. We have further evidence that NR raises NAD+ in white blood cells and in plasma in humans. This will be the first trial to examine whether NR raises NAD+ in the brains of humans. Since concussion activates the DNA repair enzyme PARP-1 (which consumes and lowers NAD+ in the brain), the possibility that NR might raise brain NAD+ levels opens an exciting new frontier in how we might be able to manage football-related concussion and other forms of traumatic brain injury in the near future.”

Frank Jaksch Jr., founder and CEO of ChromaDex, commented “We are honored to collaborate with Dr. Zhu and Dr. Bauer and their respective research teams, as well as Thorne Research on this clinical trial. The human study is designed to provide a better understanding on how NR may affect brain NAD+ levels in athletes who participate in football and other contact sports.”

Thorne Research introduced NiaCel® in 2014, which features ChromaDex’s patented ingredient NIAGEN®, the first and only commercially available form of nicotinamide riboside (NR), a naturally occurring vitamin B3 metabolite found in milk.

ChromaDex, through more than 50 collaborations with researchers around the world, is in the forefront of research showing that the use of NR helps preserve or restore mitochondrial function and may be beneficial in treating and/or preventing disease.

About Nicotinamide Riboside (NR)

Published research has shown that NR is perhaps the most effective precursor to boost the co-enzyme NAD+ in the cell. NAD+ is arguably the most important cellular co-factor for improvement of mitochondrial performance and energy. In recent years, NAD+ has been shown to be essential in supporting healthy cellular metabolism, including the efficient conversion of blood glucose into energy.

As organisms age, NAD+ levels drop, which leads to a decrease in mitochondrial health; this in turn leads to age-related health issues. Low NAD+ levels limit activity of a group of enzymes called sirtuins, which are believed to play a key role in longevity. NAD+ levels can be depleted by lifestyle choices such as overeating and lack of exercise. By boosting NAD+, NR can increase mitochondrial health and induce creation of new mitochondria.

About Thorne Research

Thorne Research is a personalized health solutions company dedicated to improving individual outcomes through science and technology. For 30 years, Thorne Research has led the industry in providing clinically proven, high quality natural products including foundational vitamins and minerals, therapeutic focused nutritional supplements, and soon to include medical foods and botanical drugs. By leveraging cutting-edge research and personalized data through affiliate WellnessFX, Thorne Research offers customized preventive health solutions for practitioners and their patients. Thorne Research is a majority shareholder in WellnessFX, a San Francisco-based personalized wellness company, providing home kit testing and actionable recommendations from the analysis of blood chemistry, genetics, and microbiome.

Thorne Research is headquartered in New York City with a manufacturing facility in Sandpoint, Idaho. Further information on Thorne Research is available at Thorne.com.

About ChromaDex

ChromaDex leverages its complementary business units to discover, acquire, develop and commercialize patented and proprietary ingredient technologies that address the dietary supplement, food, beverage, skin care and pharmaceutical markets. In addition to our ingredient technologies unit, we also have business units focused on natural product fine chemicals (known as "phytochemicals"), chemistry and analytical testing services, and product regulatory and safety consulting (known as Spherix Consulting). As a result of our relationships with leading universities and research institutions, we are able to discover and license early stage, IP-backed ingredient technologies. We then utilize our in-house chemistry, regulatory and safety consulting business units to develop commercially viable ingredients. Our ingredient portfolio is backed with clinical and scientific research, as well as extensive IP protection. Our portfolio of patented ingredient technologies includes NIAGEN™ nicotinamide riboside; pTeroPure® pterostilbene; PURENERGY™, a caffeine-pTeroPure co-crystal; and ProC3G™, a natural black rice containing cyanidin-3-glucoside. To learn more about ChromaDex, please visit www.ChromaDex.com.

About The University of Minnesota Clinical and Translational Science Institute

The University of Minnesota Clinical and Translational Science Institute (CTSI) at the University of Minnesota's (UMN) Academic Health Center is supported through the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program. The institute is one of approximately 60 medical research institutions working together to improve the way clinical and translational research is conducted nationwide, enhancing its efficiency and quality. The CTSA consortium aims to accelerate the process of translating laboratory discoveries into treatments for patients, to engage communities in clinical research efforts, and to train a new generation of clinical and translational researchers.

About The Mayo Clinic Complementary and Integrative Medicine Program

The Mayo Clinic Complementary and Integrative Medicine Program was founded in 2001 as a program within the Department of Medicine at Mayo Clinic. The program was specifically created to help address the ever increasing patient interest in wellness-promoting activities that have not typically been part of conventional medical care. The program offers wellness-promoting treatments that complement conventional Western medical care. Mayo Clinic is a nonprofit organization committed to medical research and education, and providing expert, whole-person care to everyone who needs healing. For more information, visit mayoclinic.org/about/ and mayoclinic.org/news.

Forward-Looking Statements:

This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended. Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects", "anticipates", "intends", "estimates", "plans", "potential", "possible", "probable", "believes", "seeks", "may", "will", "should", "could" or the negative of such terms or other similar expressions. Actual results may differ materially from those set forth in this release due to the risks and uncertainties inherent in ChromaDex's business. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended January 3, 2015, ChromaDex's Quarter Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof.

Statements in this press release have not been evaluated by the Food and Drug Administration. Products or ingredients are not intended to diagnose, treat, cure or prevent any disease.

Contacts

Investor Contact for ChromaDex
The Del Mar Consulting Group, Inc.
Robert B. Prag, President
858-794-9500
bprag@delmarconsulting.com

ChromaDex
Andrew Johnson, Director of Investor Relations
949-419-0288
andrewj@chromadex.com

Thorne Research
Michelle Crow
858-245-8867
mcrow@thorne.com

It’s All About NAD

Why NAD?

As research reveals more information about metabolism and aging, we increasingly find at the center of this complex web of enzymes and biochemical markers a coenzyme found in all living cells – nicotinamide adenine dinucleotide (NAD). The amount of NAD in the body declines naturally with aging, and in doing so the activities of numerous enzymes are correspondingly decreased. The sirtuin (SIRT) family of proteins, which rely heavily on the presence of NAD, have been studied for many years for their role in metabolism and aging. To date, seven SIRT protein subtypes have been identified, each of which have a slightly different activity, location, and overall function. Because SIRT activity is dependent on NAD, these two compounds are linked to cellular lifespan, metabolism, and even regulation of inflammation.

Because NAD pools decline naturally during the aging process, SIRT function will decline as well. A decline in SIRT1 activity will impact mitochondrial function in two ways.  First, a decline in SIRT1 has been linked to decreases in mitochondrial biogenesis via transcriptional activator PGC1α.  Second, decreased SIRT1 activity leads to decreased mitochondrial function due to a reduction in mitochondrial DNA replication and transcription. Because the mitochondria are the energy powerhouses in every cell of the body, a decline in mitochondrial function has now been linked to many age-associated pathologies, including metabolic syndrome, obesity, neurodegenerative issues, and cognitive decline.

Since one in three adults has metabolic syndrome, the importance of the SIRT family of proteins to metabolism cannot be over-emphasized. A recent study found that individuals with fatty liver who had a specific single nucleotide polymorphism (SNP) for SIRT3 were more likely to progress to metabolic syndrome.

How do we increase NAD?

What can we do to increase NAD in the body? It turns out that recent clinical research has found that nicotinamide riboside (NR) – a newly-researched vitamin B3 analog – can increase NAD levels in healthy humans – indicating that NR crosses into the mitochondria and increases NAD levels.* Click here for more information: http://www.news-medical.net/news/20150211/First-human-clinical-study-of-ChromaDexs-NIAGEN-nicotinamide-riboside-meets-primary-endpoint.aspx

How does NR affect metabolism?

The use of NR to increase NAD has been studied in animal models of metabolic syndrome. Because NR leads to increased SIRT1 and SIRT3 activity, the clinical ramifications for human use are extensive, and include: (1) a decrease of fatty liver incidence from a high-fat, high-sucrose diet; (2) a decrease in hepatic insult in models of type 2 diabetes; (3) an increase in cholesterol metabolism through SIRT1 activation; and (4) better weight management in high-fat diets.*

To summarize, NR can increase NAD, which can upregulate SIRT1 and SIRT3.*

Increased SIRT1:

  • inhibits hepatic glucose formation in obesity*
  • limits hepatic lipid accumulation in the presence of elevated blood sugar*
  • promotes the production of good (HDL) cholesterol*
  • supports insulin release, improving overall glucose tolerance*
  • enhances leptin sensitivity*

Increased SIRT3:

  • inhibits lipid accumulation in the liver*
  • increases mitochondrial biogenesis in skeletal muscle*
  • increases thermogenesis in brown fat stores*

The bottom line – it’s all about NAD! 

References

  1. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol 2014;24(8):464-471.
  2. Cantó C, Houtkooper R, Pirinen E, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012;15(6):838-847.
  3. Hirschey M, Shimazu T, Jing E, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011;44(2):177-190.
  4. Imai S. "Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta 2010;1804(8):1584-1590.
  5. Sasaki T. Age-associated weight gain, leptin, and SIRT1: a possible role for hypothalamic SIRT1 in the prevention of weight gain and aging through modulation of leptin sensitivity. Front Endocrinol (Lausanne) 2015;6:109.
  6. First human clinical study of ChromaDex's NIAGEN® nicotinamide riboside meets primary endpoint. http://www.news-medical.net/news/20150211/First-human-clinical-study-of-ChromaDexs-NIAGEN-nicotinamide-riboside-meets-primary-endpoint.aspx  [Accessed March 9, 2016]
How to Choose the Right Supplement Company

In this video, Brent Bauer, MD, director of the Mayo Clinic Complementary and Integrative Medicine Program, shares insights about wellness, the nutritional supplement industry, and use of supplements. Dr. Bauer discusses various aspects of the nutritional supplement industry.



Topics covered by Dr. Bauer include:

  • Why Mayo Clinic has an interest in complementary medicine, and how Mayo’s involvement benefits ingredient research and supplement companies and patients alike.
  • How the FDA really does regulate the nutritional supplement industry and how FDA’s regulation compares to the pharmaceutical industry.
  • What everyone should know about how nutritional supplements are made before making the decision to purchase them.
  • Adverse events reporting, manufacturing certifications, and excipients used in manufacturing.

In addition, Dr. Bauer offers valuable advice to patients and practitioners about how to approach one another to discuss nutritional supplements.

All in all – it’s a great perspective that you do not want to miss!


The following is a list of Thorne Research nutritional supplement products that are currently being studied in clinical trials.

Pain in the Gut: How NSAIDs and Gut Microbes Can Affect Each Other

Understanding how medications are metabolized in the human body continues to be one of the fastest growing – and most fascinating – areas of medical research. This research includes understanding what the body does to a medication when it’s ingested – pharmacokinetics – as well as what that substance does once it’s in the body – pharmacodynamics. As we more intensely study the human genome, we are beginning to appreciate its complex and closely intertwined relationship to these areas of human physiology – what is increasingly being referred to as pharmacogenomics.

The interaction model is not yet fully complete, particularly because we need to increase our understanding how and where epigenes and epigenomics fit into it. Notwithstanding our current understanding of what the body does to an ingested substance on a genetic level, there are still a multitude of interactions we are not aware of. The newest category of interactions could be referred to as pharmacomicrobiomics – what our unique microflora arrangement will do to a substance and vice versa. Some of the very latest research is just now beginning to address this subject.

In a recently published article in the open-access scientific journal, eLife, a group of researchers began analyzing two significant interactions – how an ingested substance might change the microbiome and the effects the microbiome might have on the metabolism of the substance. The team had studied the medication indomethacin, a common medication in the non-steroidal anti-inflammatory drug (NSAID) class, which is related to ibuprofen and naproxen. Indomethacin inhibits two enzymes that produce prostaglandins, which results in an anti-inflammatory effect in the body.

But the prostaglandins that are being inhibited are in the body for a reason – they provide protection from gastric ulceration. In the first part of the study, the research team found that acute and chronic dosing of indomethacin in mice significantly altered the microbiome genomic structure such that it created a more pro-inflammatory architecture. At both dosing schedules for indomethacin – short-term and long-term – pro-inflammatory changes were observed in the GI tract. Therefore, a common side effect of indomethacin therapy, which can occur with short-term and long-term dosing, can be gastric ulceration. 

In the second part of the study, the research team treated the mice with antibiotics, then studied the pharmacokinetic and pharmacodynamic effects the altered microbiome had on indomethacin. What they observed, most likely due to bacterial enzyme changes, was that there was a higher elimination/clearance of the medication, as well as a reduction of its half-life, which would reduce its anti-inflammatory effect.  Although this might help decrease the adverse effect related to decreased prostaglandins in the gut, the decreased systemic concentration of the drug would also likely reduce its anti-inflammatory effects. These interactions would therefore result in so-called bi-directional interactions.

Although this study was done in mice, the authors concluded that, “Humans show considerable inter-individual differences in their microbiota and their responses to indomethacin – thus the drug-microbe interactions described here provide candidate mediators of individualized drug responses.”  

For more information regarding the study go to: http://www.ncbi.nlm.nih.gov/pubmed/?term=Drug-microbe+interactions

Heart-Healthy Practices: Surprising Statistics

Heart disease is currently the leading cause of death in the United States. According to the latest statistics from the U.S. Centers for Disease Control, heart disease results in 600,000 deaths each year, accounting for one of every four U.S. deaths. This is a somber statistic and it suggests most people have been affected by, or have a family member with, or have suffered a loss of a loved one from heart disease. But there is hope. As you probably know heart disease can be prevented.

In a large study known as the CARDIA study, researchers following 18-30 year-olds from the mid 1980’s to the present analyzed large amounts of data to identify cardiovascular disease (CVD) risks. What they found is quite amazing.

In a study published in 2012, it was shown that positive diet and lifestyle factors followed by young adults reduced their risk of CVD as they got older. These positive factors include a normal body mass index, limited alcohol intake, no smoking, a healthy diet, and regular physical activity. These results were found even in individuals who had a family history of heart disease – meaning nurture trumped nature!

Further analysis of the CARDIA study reveals fruit and vegetables play a significant role. Those individuals with the highest fruit and vegetable intake were shown to have the lowest coronary artery calcium on follow-up after 20 years. Coronary artery calcium is a hallmark marker for sclerotic plaque formation and CVD risk. Further studies also link shorter sleep duration to CVD risks in men. The findings show that men who have shorter objective sleep durations have a significant increased risk of CVD.

So why bring this up? To some these facts will appear to be a no brainer, but this couldn’t be further from the truth. An analysis presented at the 2015 annual American Heart Association meeting found that fewer Americans are sticking to heart-healthy practices than 20 years ago. Even with the mounting evidence we now have regarding the power of prevention for heart disease, less than six percent of the 3,460 individuals in another large longitudinal study known as the Framingham heart study were still following the guidelines for preventing cardiovascular disease.

So, to celebrate heart month, let’s focus on prevention as well as supporting cardiovascular health with short- and long-term heart healthy goals. All month long we will increase our diet, health, and lifestyle educational content as a way to help kick-start positive cardiovascular health goals for you and your patients.

References

  1. http://www.cdc.gov/heartdisease/facts.htm [Accessed January 20, 2016]
  2. Liu K, et al. Circulation 2012;125:996-1004.
  3. Miedema MD, et al. Circulation 2015;132:1990-1998.
  4. Sands MR, et al. Stroke 2012;43:2858-2864.
  5. https://www.nlm.nih.gov/medlineplus/news/fullstory_155611.html [Accessed January 20, 2016]
Thorne Research Catalog 2016

We are pleased to introduce the new digital Thorne Research Catalog. After receiving a great deal of feedback on our paper catalogs, we will now be providing information on our products electronically in order to:

  1. Provide up-to-date product listings and information through ongoing, real-time updates for new product introductions, formula changes and line extensions.
  2. Provide multiple means by which to easily find a product or class of products, through alphabetical and category indexes.  
  3. Speed and provide greater ease in finding a product(s) through hyperlinks by which you can look up a product or category in the various indexes and click through to the appropriate page, rather than having to leaf through a number of pages.
  4. Save paper and natural resources, however, you may elect to print a copy if you so choose.

You may access the new digital catalog by clicking the following link, 2016 Thorne Product Catalog, or if you are logged in as health-care practitioner you may go to our Resource Library under Product Literature.

We hope you find this new means to deliver a real-time, interactive catalog a means by which you can better serve your clients.  Feel free to contact Customer Service at 800-228-1966 with any questions or feedback you may have.  Thank you for your continued loyalty and patronage.

New England Journal of Medicine Article Claims Supplements Unsafe

An article in the October 15, 2015, New England Journal of Medicine, and quoted by numerous media outlets, reported there are an estimated 23,000 hospital emergency department visits annually in the United States due to the use of dietary supplements.  The estimate was obtained by gathering data from 63 hospital emergency departments, which reported 3,667 visits attributable to dietary supplements over a 9-year period (2004-2013).  That number was extrapolated to all U.S. hospitals, which is how the estimate of 23,000 annual ER visits was derived.

The largest portion of ER visits (41%) was related to weight loss, energy, and sexual enhancement products, with the most commonly-reported symptoms being palpitations and chest pain.  These three categories have long been a problem, with numerous products that claim to be dietary supplements being adulterated with prescription drugs or their chemical analogs.  Other products have been shown to contain stimulant drugs or caffeine – which can cause adverse reactions when taken in high doses or by susceptible individuals.  In the 20-34 age demographic, weight loss and energy products were implicated in more than 50 percent of cases.  Unsupervised ingestion by children accounted for 21 percent of cases.

It’s difficult to determine whether the estimated 23,000 ER visits is a correct number.  To arrive at an accurate estimate of ER visits attributed to reputable supplement products you should back out the above categories of spurious products, as well as the accidental ingestion by unsupervised children and the elderly – 67 percent of the reported cases in children and 62 percent in those 65 and older.  A large portion of the elderly cases was due to swallowing difficulties of large tablets or capsules, but were attributed to the intake of “micronutrient” supplements.  The researchers in the NEJM article didn’t state how many elderly individuals had difficulty swallowing large tablets or capsules, but this issue is problematic in attributing them solely to supplements, because the symptom is more related to the dosage form than the contents.  Even if the 23,000 ER visits estimate is correct, this equals only 4.6 patients per year reporting to the ER of their local hospital for an adverse event related to using a dietary supplement.  This also equals only one percent of the ER visits attributed to the proper use of prescription drugs.  According to a U.S. Health and Human Services report, 2.3 million individuals visited hospital emergency departments in 2011 for adverse events related to the proper use of prescription drugs.  Over 100,000 individuals die each year from prescription drug use.  These contrary facts point to an excellent safety record for legitimate dietary supplements.

Thorne Research takes every adverse event report seriously.  Every adverse event report is handled by an independent company that specializes in adverse event data gathering, investigation, and reporting. Adverse events are reviewed, investigated, and reported to FDA if they are deemed to be a Serious Adverse Event.  We regularly analyze adverse event reports for product, ingredient, or symptom trends, and we perform risk analyses to ensure the safety of our products.  The data reported by our independent adverse event partner shows a 0.007 percent potential risk (seven one-thousandths of one percent) of having an adverse event per bottle of a Thorne Research supplement, which equates to a 0.0002 percent potential risk (two ten-thousandths of one percent) of experiencing an adverse event from one dose of one of our supplement products – a 1 in 457,068 chance.  And the majority of these reported adverse events are gastrointestinal in nature, mild, and self-limited.

Summary:

  • Thorne Research has a robust adverse event reporting program.
  • The risk of an adverse event cause by a reputable supplement product is less than one percent of having an adverse event caused by a prescription medication.
  • An independent, third-party company that specializes in adverse event information gathering, investigation, and reporting handles our adverse events.
  • We perform a thorough trend analysis of our adverse event reports.
  • The risk of experiencing an adverse event from a Thorne Research product is incredibly small.
UNPA/AHPA/CHPA/CRN/NPA Media Release
Physician Provides Data on Americans’ Alarming Nutrient Deficiencies at Congressional Dietary Supplement Caucus Briefing
 
CDC data show that Americans don’t get sufficient essential nutrients from food alone
WASHINGTON (Sept. 11, 2015) — Data from the Centers on Disease Control and Prevention (CDC) show that tens of millions of Americans aren’t getting enough essential nutrients to ensure their bodies function optimally, a stark contrast to headlines and soundbites that assert Americans get the nutrients they need from food alone.

The CDC data was presented by Tieraona Low Dog, M.D., nationally recognized physician, author and speaker, to congressional staffers at a Sept. 9 educational briefing, “Life Fortified: A Physician’s Case for Dietary Supplements,” held by the Congressional Dietary Supplement Caucus (DSC) in cooperation with the leading trade associations representing the dietary supplement industry: the American Herbal Products Association (AHPA), the Consumer Healthcare Products Association (CHPA), the Council for Responsible Nutrition (CRN), the Natural Products Association (NPA), and the United Natural Products Alliance (UNPA).
 
Citing CDC data, Dr. Low Dog highlighted that nearly 90 million Americans have a vitamin D deficiency, 30 million Americans are deficient in vitamin B6, 18 million Americans are deficient in vitamin B12 and nearly 16 million Americans have a vitamin C deficiency.
“I’m extremely concerned when I hear misleading soundbites on the evening news that people don’t need vitamins because they get all the nutrients they need from their diet because it isn’t just patients who hear this, doctors also hear it repeatedly,” Dr. Low Dog said. “This mantra that Americans get all the nutrients they need from food is simply not true and the data demonstrates it is false. It is much harder than you think to get the nutrients you need from food alone.”

Dr. Low Dog illustrated this point by outlining what the average person would need to eat in order to get the minimum recommended amount of many individual nutrients. For example, in order to get the recommended 18 milligrams of iron per day through food, you’d need to eat four cups of raisins, 15 cups of broccoli, three cups of cooked spinach, 10 ounces of beef liver, or 45 ounces of chicken breast. She noted that meeting the minimum amount of nutrition is especially difficult for low-income Americans who can use Supplemental Nutrition Assistance Program (SNAP) assistance to purchase candy and soda, but not multivitamins.

A thoughtful, coordinated approach between industry and public health initiatives is required to address the many complex factors like lower nutrient content in today’s foods and unintended consequences of well-intentioned health campaigns to avoid certain, nutrient-rich foods like egg yolks that contribute to Americans’ vitamin and mineral deficiencies, according to Dr. Low Dog.
 
The American Herbal Products Association (AHPA) is the national trade association and voice of the herbal and botanical products industry. AHPA is comprised of more than 300 domestic and foreign companies doing business as growers, processors, manufacturers, and marketers of herbs and herbal products, including foods, dietary supplements, cosmetics, and non-prescription drugs. Founded in 1982, AHPA's mission is to promote the responsible commerce of herbal products. Website: www.ahpa.org.
 
The Consumer Healthcare Products Association (CHPA) is the 133-year-old-trade association representing the leading manufacturers and marketers of over-the-counter medicines and dietary supplements. Every dollar spent by consumers on OTC medicines saves the U.S. healthcare system $6-$7, contributing a total of $102 billion in savings each year. CHPA is committed to promoting the increasingly vital role of over-the-counter medicines and dietary supplements in America’s healthcare system through science, education, and advocacy. Visit www.chpa.org and www.otcsafety.org.
 
The Council for Responsible Nutrition (CRN), founded in 1973, is a Washington, D.C.-based trade association representing 150+ dietary supplement and functional food manufacturers, ingredient suppliers, and companies providing services to those manufacturers and suppliers. In addition to complying with a host of federal and state regulations governing dietary supplements and food in the areas of manufacturing, marketing, quality control and safety, our manufacturer and supplier members also agree to adhere to additional voluntary guidelines as well as to CRN’s Code of Ethics. Visit www.crnusa.org. Follow us on Twitter @crn_supplements and @wannabewell and on Facebook.
 
The Natural Products Association (NPA) is the trade association representing the entire natural products industry. We advocate for our members who supply, manufacture and sell natural ingredients or products for consumers. NPA has set numerous industry standards, such as dietary supplement Good Manufacturing Practices (GMPs), as well as a definition of natural for home care and personal care products. NPA, which represents over 2,000 members accounting for more than 10,000 locations of retailers, manufacturers, wholesalers and distributors of natural products, including foods, dietary supplements, and health/beauty aids, has led the charge to keep the natural products industry in business for 79 years. Visit www.NPAinfo.org.

The United Natural Products Alliance (UNPA) is an international trade association representing many leading natural products, dietary supplement, functional food, scientific and technology and related service companies that share a commitment to provide consumers with natural health products of superior quality, benefit and reliability. Founded in Utah in 1991, UNPA was instrumental in the passage of the 1994 Dietary Supplement Health and Education Act (DSHEA) and continues to take a leadership position in legislative and regulatory issues and industry best practices. Visit www.unpa.com.
   
Thorne Research Announces Health and Wellness Content Agreement with Mayo Clinic

Thorne Research Inc., a leader in prevention, wellness, and health solutions, today announced a content agreement with Mayo Clinic. Under the new agreement, Mayo Clinic will provide Thorne Research with accurate, authoritative health information to offer to its clients.

Starting in August, 2015, Thorne Research will feature on its website Mayo Clinic’s extensive library of patient-centered health and wellness content, focusing on nutrition, exercise, lifestyle, and supplementation. In addition, Mayo Clinic will develop content to further address topics such as pain management, brain health, the aging process and more. Emphasis will also be placed on how to incorporate supplementation into the context of healthy eating and healthy living.

“There is a huge need in the marketplace for reliable, research-based health information, especially as people increasingly turn to the internet and mobile apps for healthcare answers and solutions,” said Paul Jacobson, CEO of Thorne Research. “At Thorne Research, we want to provide people with the information and tools needed to lead healthier lives. This includes not only providing high quality, nutritional supplements and digital health assessment displays, but also providing research-based education. There is no one better than Mayo Clinic to help us realize this vision.”

“Mayo Clinic continues to look for new ways to deliver health care information to patients worldwide,” said John Wald, M.D., Medical Director, Mayo Clinic Public Affairs. “This agreement gives Thorne Research access to Mayo’s library of health care content for its customers worldwide.”

In addition, Thorne Research will be actively seeking partnerships with organizations and networks that are looking for product, technology, and content solutions. By combining high quality, science-based nutritional supplements, technology platforms, including digital assessment displays and a telehealth platform, with reliable, research-based education, Thorne Research is positioned to become the leader in providing comprehensive solutions to improve one’s quality of life.

To learn more about Thorne Research, visit www.thorne.com.

About Thorne Research
Thorne Research is a global healthcare company dedicated to improving the health and wellness of people through science and technology. With a portfolio of trusted, quality, science-based offerings in nutritional supplements and lifestyle management, Thorne Research serves people around the world, targeting a number of health areas, such as cardiovascular health, metabolic health, cancer supportive care, skin care, healthy aging, and sports performance. Thorne Research is headquartered in New York City with a manufacturing facility in Sandpoint, Idaho.

About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit mayoclinic.org/about/ and mayoclinic.org/news.

Download the Press Release

Magnesium Helpful for Pregnancy-Induced Leg Cramps

Leg cramps are common in pregnant women and are very uncomfortable. In a double-blind, placebo-controlled, four-week trial of magnesium supplementation in 86 healthy pregnant women, leg cramp frequency and severity were studied. In the group who took 300 mg magnesium daily, significant reductions were demonstrated in leg cramp frequency and intensity compared to placebo.

Supakatisant C, Phupong V. Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Matern Child Nutr 2015;11:139-145.

Computer-Related Dry Eyes Relieved by Fish Oil

While too much computer screen time can cause dry eyes, recent research has shown that intake of omega-3 fatty acids from fish oil can help dry eye symptoms. In a study of 478 people with dry eyes who spent significant amounts of time at the computer, a fish oil supplement improved their dry eye symptoms. In the individuals in the study who took a modest amount of fish oil daily – 360 mg of EPA and 240 mg of DHA – 70 percent were symptom-free after three months. In the placebo group, only 15 percent had symptom relief.

Bhargava R, Kumar P, Phogat H, et al. Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye. Contact Lens and Anterior Eye 2015;38:206-210.

Dr. Robert Rountree Receives 2015 IFM Award

Thorne Research’s Chief Medical Officer, Robert Rountree, MD, has been named the recipient of the 2015 Linus Pauling Award at the Institute for Functional Medicine’s 2015 Annual International Conference.  This award is a testament to the significant contributions Dr. Rountree has made to the field of Functional Medicine.  In combination with his private practice, his contributions to Thorne Research, and his educational lecturing around the world, Dr. Rountree continues to influence the way health-care practitioners and patients approach preventative medicine.

Thorne Research’s President, Will McCamy, said this about Dr. Rountree:  “We could not be more proud of Dr. Rountree and his receiving this honor from the IFM community.  Bob’s unwavering commitment to educating his fellow practitioners on a functional medicine approach has significantly impacted how thousands of patients receive treatment today.”

To learn more about this award, please visit the following site: https://www.functionalmedicine.org/news.aspx?state=2&news=97

Skipping Breakfast - a Risk Factor for Heart Disease

Everyone knows that the types of foods you eat have a major impact on your health. As it turns out, when you eat could be almost as important. A new study published July 23, 2013, in the journal Circulation revealed that men who skip breakfast are 27 percent more likely to develop heart disease than men who begin each day with a meal. And men who eat late at night have a 55 percent higher risk for cardiovascular disease than those who go to bed on an empty stomach.

Previous trials have shown that adults who skip meals are more likely to exhibit certain cardiovascular risk factors, such as excessive body weight, hypertension, dyslipidemia, insulin resistance or type 2 diabetes. Habitually skipping breakfast, for example, can increase your chances for significant weight gain by 15 percent and heighten your risk for type 2 diabetes by over 20 percent. Until now, however, no study has linked poor eating patterns to coronary heart disease.

While people who skip breakfast may also engage in other behaviors that increase cardiac risk – smoking, physical inactivity or consuming too much alcohol, for example – missing the most important meal of the day might confer some physiologic costs that are independent of these behaviors. Compared to people who spread their daily energy intake over three or more meals, individuals who consume all of their daily caloric needs at one sitting tend to have higher LDL-C, triglyceride, apolipoprotein-B and blood pressure levels.

Finally, breakfast is more likely than any other meal to be composed of healthier foods, such as yogurt, fruit or whole-grain cereal or breads. When these foods are chronically supplanted by less wholesome items, the undesirable effects begin to stack up.

Cahill LE, Chiuve SE, Mekary RA, et al. Circulation 2013;128:337-343.
http://circ.ahajournals.org/content/128/4/337.full

Can Targeted Supplementation Reduce Health Care Costs?

Critics of the dietary supplement industry are quick to point out studies that suggest supplements don’t work and are a waste of consumers’ money. But if health-care policymakers become aware of a study published last year in the Journal of Dietary Supplements, such criticism could finally be relegated to the dustbin. According to Drs. Christopher Shanahan and Robert de Lorimier, who collaborated with Frost & Sullivan’s Health Care and Life Sciences Team to gather data for the study, the routine use of omega-3 supplements and B vitamins by individuals who have coronary heart disease could save billions of dollars in health care costs. Those are the kinds of numbers that change the way doctors practice medicine.

Coronary heart disease (CHD), a condition that affects 16 percent of Americans over the age of 55, causes 385,000 deaths and accounts for one of every six fatalities in the United States each year. The hospital-related costs for treating CHD patients now surpasses $100 billion per year, with costs for individuals over age 55 accounting for 60 percent of that figure. In order to determine whether the daily use of supplements at preventive intake levels could impact the financial burden of CHD-related events, Shanahan and de Lorimier analyzed 17 peer-reviewed, published studies evaluating the relationship between omega-3 or B vitamin supplementation and CHD-associated hospital utilization costs.

According to these researchers, if all Americans over the age of 55 with CHD took an omega-3 supplement every day, the average savings in avoided hospitalization costs would be over $2 billion annually. For users of B vitamins (specifically B6, B12 and folic acid), the savings for CHD-related hospitalizations would average $1.52 billion per year. Over the eight-year period from 2013 to 2020, after accounting for the cost of the supplements, the country would realize a net savings of more than $9 billion if everyone in this high-risk group used both omega-3s and B vitamins – that’s money America’s health insurance companies (not to mention its citizens) would like to keep in their pockets.

Drs. Shanahan and de Lorimier designed their study to examine the societal impacts associated with targeted supplementation in an at-risk population. What they couldn’t fully explore were the benefits individual CHD patients might reap from consuming a few dollars’ worth of supplements every month. Despite the lack of this additional information, it seems reasonable to assume that, in addition to saving money by staying out of the hospital, people with CHD stand to gain something even more valuable from supplementation: improved quality of life.

Reference
Shanahan CJ, de Lorimier R. J Diet Suppl 2014 Aug 28 [Epub ahead of print]

Vitamin D Insufficiency May Impair Athletic Performance

Almost every schoolchild knows that vitamin D – the "sunshine vitamin" – is important for building strong bones. After all, for nearly five decades following its discovery, scientists believed vitamin D was primarily involved in regulating calcium absorption and maintaining skeletal health, and most people still think of it that way. Within the last 40 years, however, researchers have learned that vitamin D behaves more like a hormone than a vitamin, and scientists are currently exploring its roles in electrolyte metabolism, protein synthesis, immunity, nerve and muscle function, and an array of other physiologic processes.

Over 75 percent of Americans could be vitamin D "insufficient", meaning they get enough vitamin D to avoid deficiency but not enough to maintain optimal healthy levels. In elderly individuals, vitamin D insufficiency has been linked to muscular weakness, poor balance, delayed reaction time, and a higher risk for falls and fractures. A review in the May 2013 issue of Nutrients suggests that even mildly low vitamin D levels can adversely affect young people, too, and such insufficiency could be particularly consequential in athletes. According to Dana Storlie-Ogan, a nutritionist at Central Washington University in Ellensburg, Washington, athletes who do not get enough vitamin D might find their performance lagging, they may require longer recovery times, and they could be more prone to stress fractures and muscle injuries. Athletes who participate in indoor sports are especially likely to develop vitamin D insufficiency.1

The average person needs at least 3,000 to 5,000 IU of vitamin D every day.2 Since vitamin D participates in metabolic pathways that are "up-regulated" during exertion, physically active people require more vitamin D for peak performance. Storlie-Ogan advises athletes to have their vitamin D status evaluated and adjust their vitamin D intake to maintain a serum 25(OH)D level above 40 ng/mL.

1. Ogan D, Pritchett K. Nutrients 2013;5(6):1856-1868.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725481/pdf/nutrients-05-01856.pdf

2. Holick MF. J Nutr 2005;135(11):27395-27485.
http://jn.nutrition.org/content/135/11/2739S.long

Extract from Broccoli Can Temporarily Alleviate Autism Symptoms

Autism spectrum disorder (ASD) is a condition that affects 1 in 68 persons in the United States. ASD is characterized by deficits in communication, impaired social interaction, and repetitive or obsessive behaviors. Boys are four times more likely than girls to suffer from ASD. The cause(s) of ASD are unknown, although genetic factors and environmental factors both appear to be involved. The level of disability associated with ASD ranges from mild to severe.

At the present time there is no cure for ASD, so treatment is aimed at relieving specific symptoms and improving an affected individual’s function. Interestingly, many parents of autistic children report that ASD symptoms temporarily improve when their children develop a fever. The factors involved in this so-called “fever response” have not yet been identified, although some experts believe that a fever can awaken one or more protective mechanisms within the brain that are otherwise dormant in individuals with ASD. As a result of recent research on broccoli sprout extract conducted at Massachusetts General Hospital’s Lurie Center for Autism, we might be one step closer to understanding why fever can alleviate the symptoms of ASD, which could lead to new treatments.

In a Massachusetts General Hospital clinical trial involving 44 young men with ASD, daily administration of sulforaphane – an extract derived from broccoli sprouts – substantially improved behavior and communication in the young men who received the treatment. Individuals who received only a placebo showed no improvement. When the treatment group stopped taking sulforaphane at the end of the trial, they returned to pre-treatment status, indicating that it was the sulforaphane that reduced the ASD symptoms in these individuals.

Sulforaphane is known to positively impact many of the physiologic abnormalities associated with ASD, such as excessively high oxidative stress, poor mitochondrial function, and inflammation within nerve cells. According to the scientists at Massachusetts General Hospital, sulforaphane probably triggers cellular processes that mimic the fever response in individuals with ASD. Although this research is only preliminary, it provides valuable insight into the underlying mechansims of a complex disorder.

Reference
Singh K, Connors S, Macklin E, et al. PNAS 2014;111(43):15550-15555.

Mentions

When you tour the Thorne Research plant you will learn why I prescribe Thorne Research products with total confidence to my allergic and highly sensitive patients. It's confidence I don't have when patients use products that rarely meet GMP standards."

— Robert Martinez, DC, ND

Students of the supplement industry — especially the rarified airs of its professional lines and practitioner sales channel — should begin to take careful notes on Thorne Research."

— Nutrition Business Journal, January 2014

I've been using Thorne Research products for over 10 years because of their purity and because they work."

— Jeffrey Morrison, MD

It is critical to use high-quality supplements so your results are predictable, dependable, and consistent with the best available research. Thorne Research is a company you can trust for your patients to receive reliable results."

— Trina Seligman, ND, LAc, Evergreen Integrative Medicine LLP

Thorne Research is a leader and innovator in the professional supplement world - not only in their products but also in education and research"

— Brooke Azie-Rentz, ND, Integrated Health Center