Methyl-Guard Plus®

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Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation*

Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.

Ingredient Information

Geometric Shape

Key Ingredients


Ingredient Amounts

Serving Size: 1 Capsules
Servings Per Container: 90
Name Amount
Betaine Anhydrous (Trimethylglycine) 600mg
Folate (L-5-MTHF) 1mg
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 30mg
Vitamin B12 (as Methylcobalamin) 1mg
Vitamin B6 (as Pyridoxal 5'-Phosphate) 15mg
Other Ingredients: Calcium (Citrate), Calcium Laurate, Hypromellose Capsule

Methyl-Guard Plus® Details

Various conditions and stressors can have an adverse impact on the body’s methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally.

Thorne’s Methyl-Guard Plus features betaine (trimethylgycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body’s methylation challenges.


Benefits of Thorne’s Methyl-Guard Plus:

  • Enhanced cellular energy production fights fatigue
  • Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health
  • Promotes fat metabolism and lean body composition
  • Promotes liver detoxification of many substances, including hormones like estrogen


Why is methylation important:

Methylation is a simple reaction where a small molecule known as a “methyl group” is transferred from one substance to another. Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in:

  • Cardiovascular health
  • Cellular energy production
  • Fat metabolism
  • DNA production
  • Liver detoxification processes


Who can benefit from Thorne's Methyl-Guard Plus:

  • Individuals with mutations to MTHFR and other genes that adversely affect methylation
  • Aging individuals wanting to support their cardiovascular, cognitive, and metabolic health
  • Women seeking support for estrogen metabolism and bone health
  • Individuals wanting nutritional support for fat metabolism and maintenance of a healthy body composition
  • Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables


Features of Thorne's Methyl-Guard Plus:

  • Betaine, also known as trimethylglycine, is a superior methyl donor 
  • The methylated forms of vitamin B12 (methylcobalamin) and folate (5-MTHF) benefit individuals with certain gene mutations
  • Active forms of vitamins B2 and B6 – key cofactors in methylation processes
  • B vitamins in their active, tissue-ready forms means your body gets the greatest benefit with the least additional work
  • Robust methylation support in fewer capsules per day than Thorne’s original Methyl-Guard®

Warnings

Risk Information: Consult a health-care practitioner prior to use If you are pregnant or breastfeeding, or if you have high cholesterol. 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate’s anti-neoplastic activity.

Keep out of reach of children. Do not use if security seal inside the cap is broken. Store tightly sealed in a cool, dry place.

Risk Information: Consult a health-care practitioner prior to use If you are pregnant or breastfeeding, or if you have high cholesterol. 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate’s anti-neoplastic activity.

Keep out of reach of children. Do not use if security seal inside the cap is broken. Store tightly sealed in a cool, dry place.

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Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation*

Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.

Thorne Verified

How to Use

Recommended Use or Purpose: Helps to form red blood cells. Helps to support liver function. Helps support healthy homocysteine levels for the maintenance of cardiovascular health. Methylation support: Methylation - the addition of a methyl group (CH4 - one carbon attached to three hydrogens) to another molecule - is an essential and vital biochemical process within the human body that is involved in a large number of biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Recommended Dose (Adults): Take 1 capsule daily or as recommended by your health professional.

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