Enhances liver detoxification and supports the metabolism of hormones and xenobiotics*
Calcium D-Glucarate (CDG) has been shown to promote liver detoxification by preventing recycling of undesirable hormones and environmental toxins.* It also helps maintain normal cholesterol levels.*
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How does it work?
Glucuronidation is the liver's normal process of attaching a glucuronic acid molecule to potentially harmful substances to detoxify and eliminate them from the body.* During phase II liver detoxification, certain hormones and various fat-soluble toxins will undergo glucuronidation and be excreted through the bile or urine. Calcium D-Glucarate helps this elimination process to occur uninterrupted.*
The more detailed version: Upon ingestion and exposure to the acidic environment of the stomach, Calcium D-Glucarate is metabolized to form D-glucaric acid. D-glucaric acid is further metabolized in the gastrointestinal tract into three compounds that exist in equilibrium and are comprised of approximately 40-percent D-glucaric acid, 30-percent D-glucaro-1,4-lactone, and 30-percent D-glucaro-6,3-lactone. These compounds are then transported to the blood and various internal organs, and subsequently excreted in the urine and bile. Although D-glucaro-1,4-lactone is apparently the most pharmacologically active of the three, it is not commercially available. Also, Calcium D-Glucarate administration results in longer inhibition of beta-glucuronidase (five hours versus one hour) than does D-glucaro-1,4-lactone, so it is the compound used.*
Calcium D-Glucarate's detoxifying and chemopreventive properties are attributable to its ability to increase glucuronidation, and the accompanying excretion of harmful compounds.* It does so by inhibiting the enzyme beta-glucuronidase.* During Phase II detoxification, hormones and various undesirable lipid-soluble toxins are bound to glucuronic acid in the liver (glucuronidation) and excreted through the biliary tract; however, beta-glucuronidase can unbind these toxins, which makes it possible for them to be reabsorbed rather than excreted. D-glucaro-1,4-lactone is the metabolite that most inhibits the activity of beta-glucuronidase, thereby increasing the excretion of toxic compounds and decreasing the activity of harmful substances that are most active in their unbound state.* Inhibition of beta-glucuronidase by Calcium D-Glucarate metabolites ultimately results in potentially decreasing the risk of toxicity.*
In addition, by reducing the activity of beta-glucuronidase and the viability of harmful intestinal bacteria, the salts of D-glucaric acid have been shown to enhance enterohepatic circulation and reduce cholesterol synthesis, thus resulting in maintenance of healthy cholesterol levels.*
Calcium D-Glucarate 500 mg.
Other Ingredients: Hypromellose (derived from cellulose) capsule, Silicon Dioxide.
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
If pregnant, consult your health professional before using this product.
There are no known adverse interactions or contraindications at publication date.
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