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Milk thistle-phospholipid complex for superior absorption
Milk thistle contains multiple constituents with strong antioxidant activity that protect liver cells from free radical damage, strengthen liver cell membranes, and help maintain the liver's built-in antioxidant system by enhancing the liver’s production of glutathione and superoxide dismutase (SOD).* Delivery in a phytosome format allows for superior absorption compared to conventional milk thistle products.
Siliphos® from Indena, the developers of phytosome technology, is a patented form of the milk thistle flavonoid silybin that is bound to phospholipids for superior absorption. The combination provides the liver-supportive benefits of silybin and phosphatidylcholine in one compound.* Silybin, the most active and potent flavonoid in the silymarin complex, is naturally water soluble, but it is made lipid-friendly by being complexed with phospholipids. The result is that, in addition to superior absorption into the bloodstream, the phytosome preparation achieves better incorporation of this liver-protective flavonoid into liver cell membranes.* A study showed evidence of direct delivery into the hepatocytes (liver cells).*
Recent analyses have revealed that some milk thistle raw materials are depleted of their active components. However, Indena’s Siliphos is standardized for its silybin content. In addition, Thorne tests every lot of finished product to assure it contains the proper amount of silybin.
The effects of Realsil (silybin-phospholipid-vitamin E complex) on liver enzymes… : a systematic review and meta-analysis of RCTS. Acta Endocrinologica (Buchar) 2020;16(2):223-231.. Derakhshandeh-Rishehri SM, Heidari-Beni M, Eftekhari MH.
A new silybin-vitamin E-phospholipid complex improves insulin resistance… : preliminary observations.. Gut 2006;55(6):901-902. . Federico A, Trappoliere M, Tuccillo C, et al.
Silybin combined with phosphatidylcholine and vitamin E in patients… a randomized controlled trial. Free Radical Biology and Medicine 2012;52(9):1658-1665. . Loguercio C, Andreone P, Brisc C, et al.
Metabolic and vascular effects of silybin… . . Internal and Emergency Medicine 2019;14(1):77-84. . Sciacqua A, Perticone M, Tripepi G, et al.
Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients…. Expert Review of Gastroenterology & Hepatology 2015;9(4):519-527. . Abenavoli L, Greco M, Nazionale I, et al.
Polyphenols: food sources and bioavailability. . American Journal of Clinical Nutrition 2004;79:727-747.. Manach C, Scalbert A, Morand C, et al.
Pharmacokinetics of silybin following oral administration of silipide . . . . . Cancer Prevention Research (Phila) 2016;9(1):89-95. . Lazzeroni M, Guerrieri-Gonzaga A, Gandini S, et al.
A phase I and pharmacokinetic study of silybin-phytosome . . . . . Investigational New Drugs 2007;25:139-146.. Flaig T, Gustafson D, Su L, et al.
A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). . Alternative Medicine Review 2005;10:193-203.. Kidd P, Head K.
The Bisphenol A induced oxidative stress in non-alcoholic fatty liver disease male patients: a clinical strategy to antagonize the progression of the disease.. International Journal of Environmental Research and Public Health 2020;17(10):3369. . Federico A, Dallio M, Gravina AG, et al.
The effects of Realsil (silybin-phospholipid-vitamin E complex) on liver enzymes… : a systematic review and meta-analysis of RCTS. Acta Endocrinologica (Buchar) 2020;16(2):223-231.. Derakhshandeh-Rishehri SM, Heidari-Beni M, Eftekhari MH.
A new silybin-vitamin E-phospholipid complex improves insulin resistance… : preliminary observations.. Gut 2006;55(6):901-902. . Federico A, Trappoliere M, Tuccillo C, et al.
Silybin combined with phosphatidylcholine and vitamin E in patients… a randomized controlled trial. Free Radical Biology and Medicine 2012;52(9):1658-1665. . Loguercio C, Andreone P, Brisc C, et al.
Metabolic and vascular effects of silybin… . . Internal and Emergency Medicine 2019;14(1):77-84. . Sciacqua A, Perticone M, Tripepi G, et al.
Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients…. Expert Review of Gastroenterology & Hepatology 2015;9(4):519-527. . Abenavoli L, Greco M, Nazionale I, et al.
Polyphenols: food sources and bioavailability. . American Journal of Clinical Nutrition 2004;79:727-747.. Manach C, Scalbert A, Morand C, et al.
Pharmacokinetics of silybin following oral administration of silipide . . . . . Cancer Prevention Research (Phila) 2016;9(1):89-95. . Lazzeroni M, Guerrieri-Gonzaga A, Gandini S, et al.
A phase I and pharmacokinetic study of silybin-phytosome . . . . . Investigational New Drugs 2007;25:139-146.. Flaig T, Gustafson D, Su L, et al.
A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). . Alternative Medicine Review 2005;10:193-203.. Kidd P, Head K.
The Bisphenol A induced oxidative stress in non-alcoholic fatty liver disease male patients: a clinical strategy to antagonize the progression of the disease.. International Journal of Environmental Research and Public Health 2020;17(10):3369. . Federico A, Dallio M, Gravina AG, et al.
