Nicotinamide Riboside

About Nicotinamide Riboside

A member of the vitamin B3 family that directly stimulates the production of NAD+, a co-enzyme that is essential to the creation of energy in the body.*

Nicotinamide riboside – or NR – is a naturally-occurring form of vitamin B3 that works within every cell to support healthy metabolism and detoxification, help us age well and exercise better, and support cognitive function.* NAD+ is arguably the most important cellular co-factor for improving mitochondrial number and function – thus having a direct beneficial impact on energy production in every cell of the body.

Unfortunately, the amount of NAD+ the body makes naturally declines as we age, with a corresponding decrease in the activity of numerous enzymes and healthy aging proteins. In addition, NR can only be obtained naturally in very small quantities from milk, fish, beer, mushrooms, green vegetables, and whole grains.

The Thorne Difference

Nicotinamide riboside that is bound to hydrogen malate is an ingredient that is exclusive to Thorne. Malate, an important Kreb’s cycle organic acid, supports NR’s  role in cellular energy production capability.*

Optimizing NR’s benefit can be further achieved when the body’s methylation processes are promoted. Researchers have found correlations between the aging of bodily tissues and the extent of DNA methylation – known as “epigenetic clocks.” The Thorne products that contain nicotinamide riboside also contain nutrients that are well known methyl donors, in contrast to NR products on the market that do not contain methyl-donating nutrients.

Products with Nicotinamide Riboside

Nicotinamide Riboside

SynaQuell™

Cognition & Focus, Sports Performance

$136
Shop Now

Cognition & Focus, Sports Performance

$136
Nicotinamide Riboside

ResveraCel®

Energy, Healthy Aging, Hormone Support, Metabolism

$58
Shop Now

Energy, Healthy Aging, Hormone Support, Metabolism

$58
See All

The Science

Weight Management

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.. Molecular Cell. 2011;44:177-190.. Hirschey M, Shimazu T, Jing E, et al.

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.. Physiological Reviews. 2012 Jul; 92:1479-1514.. Nogueiras R, Habegger K, Chaudhary N, et al.

NAD+ as a signaling molecule modulating metabolism.. Cold Spring Harbor Symposia on Quantitative Biology. 2011;76:291-298.. Canto C, Auwerx J.

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.. Cell Metabolism. 2012 Jun;15(6):838-847.. Canto C, Houtkooper R, Pirinen E, et al.

Healthy Aging

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.. PLOS ONE 2012;7:e42357.. Massudi H, Grant R, Braidy N, et al.

Age-related changes in NAD+ metabolism, oxidative stress, and SIRT1 activity in Wistar rats.. PLOS ONE. 2011;6(4):e19194.. Braidy N, Guillemin G, Mansour H, et al.

Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.. Biological Chemistry 2009;284:17110-17119.. Lu S, Kato M, Lin S.

Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.. Cell. 2013;155:1624-1638.. Gomes A, Price N, Ling A, et al.

Cognitive Support

The sirtuin pathway in ageing. . . : mechanistic and therapeutic considerations.. Lancet Neurology 2011;10:275-279.. Bonda D, Lee H, Camins A, et al.

Our Ingredients

Thorne cares deeply about where our ingredients come from. Our research and development team is tasked with sourcing exceptional ingredients, maintaining oversight of an ingredient's origin, and providing complete supply chain transparency.

We partner only with suppliers whose practices emphasize quality, science, and environmental responsibility. We believe that better ingredients mean better potency, absorption, and digestibility - and ultimately better health.

Related Health Concerns

Healthy Aging Energy Weight Management