5-MTHF; Active folate; Vitamin B9
Supports women’s reproductive health*
Promotes heart and blood vessel health*
Gnosis USA, Inc.
Spinach, collard greens, kale, Swiss chard, asparagus, broccoli, Brussels sprouts, avocado, papaya, oranges, grapefruit, strawberries, lentils, peas/split peas, and beans (pinto, kidney, black, etc.)
- Stabilized by glucosamine (not derived from shellfish)
- This form passes the gastric barrier and is absorbed mainly in the small intestine by a carrier-mediated mechanism, which ensures higher folate uptake
- Created by Gnosis, the technology leader in active folate supplementation
- Contains only the active isomer form of 5-MTHF
- Identity (HPLC)
- Specific rotation
- Heavy metals
Rai V, Yadav U, Kumar P, et al. Maternal methylenetetrahydrofolate reductase C677T polymorphism and Down Syndrome risk: a meta-analysis from 34 studies. PLoS One 2014;9(9):e108552.
Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? J Perinat Med 2013;41(5):469-483.
Seremak-Mrozikiewicz A, Drews K, Kurzawinska G, et al. The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett 2010;31(5):717-723.
Centers for Disease Control and Prevention (CDC). CDC grand rounds: additional opportunities to prevent neural tube defects with folic acid fortification. MMWR Morb Mortal Wkly Rep 2010;59(31):980-984.
Forges T, Monnier-Barbarino P, Alberto J, et al. Impact of folate and homocysteine metabolism on human reproductive health. Hum Reprod Update 2007;13(3):225-238.
Houghton L, Sherwood K, Pawlosky R, et al. [6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation. Am J Clin Nutr 2006;83(4):842-850.George L, Mills J, Johansson A, et al. Plasma folate levels and risk of spontaneous abortion. JAMA 2002;288(15):1867-1873.Cognitive Function/Mood
Mitchell E, Conus N, Kaput J. B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev 2014;47:307-320.
Lewis S, Araya R, Leary S, et al. Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. Eur J Clin Nutr 2012;66(1):97-103.
Ginsberg L, Oubre A, Daoud Y. L-methylfolate Plus SSRI or SNRI from treatment Initiation compared to SSRI or SNRI monotherapy . . . . Innov Clin Neurosci 2011;8(1):19-28.
Morris M, Jacques P, Rosenberg I, Selhub J. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in . . . cognitive test performance in American seniors. Am J Clin Nutr 2010;91(6):1733-1744.Blood Pressure Support
Cagnacci A, Cannoletta M, Volpe A. High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo-controlled study. Eur J Clin Nutr 2009;63(10):1266-1268.Homocysteine
Ambrosino P, Lupoli R, Di Minno A, et al. Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia. Nutr Res 2015;35(6):489-495.
Akoglu B, Schrott M, Bolouri H, et al. The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study. Eur J Clin Nutr 2008;62(6):796-801.Genetic Polymorphisms
Tsang B, Devine O, Cordero A, et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: A systematic review and meta-analysis of trials and observational studies. Am J Clin Nutr 2015;101(6):1286-1294.Absorption/Pharmacokinetics/Chemistry
Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica 2014;44(5):480-488.
EFSA Positive Scientific Opinion. Scientific Opinion on (6S)-5-methyltetrahydrofolic acid, glucosamine salt as a source of folate added for nutritional purposes to food supplements. EFSA Journal 2013.
Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 2010;49(8):535-548.