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Enjoy nature's calming effects

GABA – nature's calming neurotransmitter* – now available in 100 mg and 250 mg capsules

PharmaGABA-100

PharmaGABA-250

  • GABA regulates nervousness by calming excitatory neurotransmitter activity*
  • Increased GABA levels improve mental focus and relaxation, without drowsiness*
  • In at least one study, natural PharmaGABA decreased signs of stress;* synthetic GABA did not
Stress is a normal part of life. Job pressures, family contention, financial insecurity, traffic, and time management are just a few of the stressors we are faced with on a daily basis. For some people, the effects can be overwhelming, leading to feelings of nervousness. Managing stress can exert beneficial effects on the cardiovascular, immune, and neuroendocrine systems.*

Gamma-aminobutyric acid (GABA) is a major neurotransmitter widely distributed throughout the central nervous system. Because too much excitation can lead to irritability, restlessness, and sleep problems, it must be balanced with inhibition. GABA &ndash the most important inhibitory neurotransmitter in the brain &ndash provides this inhibition, acting like a "brake" during times of runaway stress.* Studies indicate GABA can improve relaxation and enhance sleep.*

A Unique, Natural GABA Formulation

PharmaGABAź is a natural form of GABA, manufactured from Lactobacillus hilgardii (the bacteria used to ferment vegetables in the preparation of the traditional Korean dish, kimchi). Natural PharmaGABA-100 (formerly named PharmaGABA-Pro) contains 100 mg GABA per capsule, while PharmaGABA-250 contains 250 mg GABA per capsule.

The Science Behind PharmaGABA

Clinical studies have shown that natural PharmaGABA increases the production of alpha-brain waves, creating a profound sense of physical relaxation while maintaining mental focus.* In contrast, stress-related beta-waves are decreased.*

A small pilot study conducted at the University of Shizuoka in Japan enrolled 13 healthy volunteers, seven males and six females, ages 21-35. EEG tracings were recorded before and after each of three administrations of 200 mL distilled water: (1) only distilled water; (2) distilled water containing 100 mg PharmaGABA; and (3) distilled water containing 200 mg L-theanine (an amino acid from green tea known to increase alpha-brain waves). Tests of the three administrations were separated by seven-day intervals. EEG recordings were made before administration, then at 0, 30, and 60 minutes after each administration for five-minute recording sessions. Alpha and beta waves were calculated as a percentage, and pre- and post-administration values were compared. Alpha-to-beta ratios were calculated as a ratio between alpha and beta percentage values. GABA produced significant effects on both increasing alpha waves (Figure 1) and decreasing beta waves, resulting in a highly significant increase in the alpha-to-beta wave ratio.*1

Figure 1. Changes in Alpha-wave Generation after
Administration of Water, L-Theanine, or Natural GABA


In addition to changes in brain waves, PharmaGABA has been shown to produce relaxation as evidenced by reduced pupil diameter, heart rate, and markers of stress &ndash salivary cortisol and chromagranin A.* In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, the synthetic GABA did not demonstrate these effects.2

A study on healthy male athletes using PharmaGABA added to a beverage showed a reduction in stress markers during and after exercise.*

Additional clinical studies with PharmaGABA yield further evidence of its anti-stress activity.*1 Secretory IgA (sIgA) is an important antibody in saliva that helps support immune function. Typically, during times of stress salivary sIgA levels drop. In one study, subjects with acrophobia (fear of heights) traversed a long walking suspension bridge that spanned a 150-foot high canyon. Salivary sIgA levels decreased when subjects were given a placebo; however, when they were given PharmaGABA, salivary sIgA levels were maintained half-way across the bridge and actually increased upon completion of the crossing (Figure 2).*

Figure 2. Salivary Secretory IgA Levels of Acrophobic
Volunteers Crossing a Suspension Foot Bridge


KEY REFERENCES:
1. Abdoua AM, Higashiguchia S, Horiea K, et al. Relaxation and immunity enhancement effects of Gamma-aminobutyric acid (GABA) administration in humans. BioFactors 2006;26:201-208.
2. Gamma-Aminobutyric Acid (GABA) Monograph. Altern Med Rev 2007;12(3):274-279.

Who Should Use PharmaGABA?

  • Anyone feeling overwhelmed or over-committed*
  • Anyone coping with mental, emotional, or physical stress*
  • People suffering from poor sleep quality*
  • Athletes engaging in strenuous workouts (that tend to elevate cortisol levels and depress immunity)*

Insomnia

Insomnia

Lifestyle tips for occasional sleeplessness

Maintaining Healthy Nerves

Maintaining Healthy Nerves

Helpful tips for maintaining a healthy immune system.

Dealing with Stress

Stress – Part of our Daily Life

Although exposure to stress is usually unavoidable, there are ways to effectively manage stress and reduce its damaging effects.


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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.