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5-MTHF 1 mg

the most biologically active form of folate*

  • a breakthrough in folate supplementation
  • the most bioavailable, active form of folate*
  • an excellent source of folate for pregnant women*
  • supports optimal cardiovascular and nerve function*

Item Product Size Price
B129 5-MTHF 1 mg 60 Vegetarian Capsules $18.65

Product Information

Folic acid must be converted to its active forms to be used by the body.* This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body's needs. Furthermore, up to 60-percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.*

Because deficiencies of folic acid have been linked to low-birth-weight infants and neural tube defects, folic acid requirements double during pregnancy.* The Centers for Disease Control and Prevention recommends folic acid supplementation for all women of childbearing age because the biggest need is during the first trimester, when a woman may not even be aware she is pregnant.* Supplementation with the more active form may be preferable.*

In concert with vitamin B12, 5-MTHF functions as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine.* Methyl-group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.*

It is important for women of childbearing age to get enough folic acid – not just those who are planning to become pregnant.* Only 50 percent of pregnancies are planned, so any woman who could become pregnant should get enough folic acid every day – especially before conception and during early pregnancy.*


Ingredients

One Capsule Contains:
Folate (as L-5-Methyltetrahydrofolate*) 1 mg.
Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

*This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-SŪ). Extrafolate-S is a registered trademark of Gnosis S.p.A.

Suggested Use: Take 1 capsule one to three times daily or as recommended by a health-care practitioner.
Please read the warnings for this product on the warnings tab.

Statements and Warnings

ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PURITY
This product does not contain wheat, gluten, corn, yeast, soy, egg, dairy products, or artificial colors, artificial sweeteners, or artificial flavors. This product also does not contain lactose, palmitic acid, magnesium stearate, or stearic acid.

PREGNANCY WARNING
If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Health-Care Professional Resources

The Importance of L-Arginine in Vascular Endothelial Function and Cardiovascular Health Webinar

Alan L. Miller, ND, Director of Medical Education and Research at Thorne Research, presents information on the essential and versatile amino acid L-arginine and its vital role in cardiovascular health. The presentation offers clinical information on how to optimize cardiovascular health by improving vascular endothelial function with L-arginine and other nutrient cofactors.

Clinical Depression: The Connections Between Fish Oil, Folate, Methylation, and Neurotransmitters Webinar

Alan L. Miller, ND, presents an intriguing look at the connections between depression, fatty acids, 5-methyltetrahydrofolate, and nutrient cofactors involved in neurotransmitter function. Dr. Miller explains how nutrient deficiencies, genetic enzyme polymorphisms, and lifestyle issues impact neurotransmitter function, and how repletion of these nutrients and enzyme cofactors support mood.

Mitochondrial Nutrients For Brain Vitality Webinar

Parris Kidd, PhD, provides a lively discussion of the research on essential nutrients for brain function, including CoQ10, lipoic acid, acetyl-L-carnitine, phosphatidylserine, benfotiamine, vitamin B12, folate, glutathione, and more. Proper function of ATP-generating mitochondria is essential to the health of every cell in the body, particularly in brain and nerve cells, and a number of nutrient cofactors are necessary for mitochondrial ATP production. Other nutrients have been researched for their ability to protect mitochondria from damage and enhance mitochondrial activity and brain function.

5-MTHF, The Active Form of Folate Webinar

Alan Miller, ND, Thorne Research's Director of Medical Education and Research, presents a concise review of the effects of 5-MTHF on neurotransmitters and blood vessel health. 5-MTHF is an essential nutrient cofactor for the production of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine, and epinephrine, which are involved in cognitive function and mood regulation. 5-MTHF is also necessary for the metabolism of homocysteine and the production of nitric oxide in vascular endothelial cells, which help promote cardiovascular health.

Stress, Mood, and Sleep Webinar

Chronic stress, nutrient imbalances, and genetic polymorphisms can all contribute to mood fluctuations, occasional anxiety, and sleep issues. Alan Miller, ND, presents an informative look at Rhodiola, 5-MTHF (active folate), GABA, 5-Hydroxytryptophan (5HTP), relaxing herbs, and neurotransmitter cofactors can help address these issues.

Gluten Sensitivity and Celiac Disease Webinar

Certified Nutritionist Tom Malterre, an expert on gluten sensitivity and celiac disease, and author of The Whole Life Nutrition Cookbook presents this fascinating look at Celiac disease and gluten sensitivity. Tom has both personal and professional insight into this condition, and offers valuable information and clinically useful pearls for the practitioner.

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